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Our studies have demonstrated that the JNK aling pathway plays an important role in ischemic brain injury and is mediated via glutamate receptor 6. Others studies have shown that N -methyl- d -aspartate NMDA receptor is involved in the neuroprotection of ischemic preconditioning. Here we examined whether ischemic preconditioning down-regulates activation of the mixed lineage kinase-JNK aling pathway via NMDA receptor-mediated Akt1 activation.


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